Penicillin G Potassium | B3131

Penicillin is a broad-spectrum β-lactam antibiotic. It binds to penicillin binding proteins (PBP). PBP catalyzes the synthesis of peptidoglycan, which is an important component of the bacterial cell wall. PBP catalyzes a pentaglycine crosslink between the alanine and lysine residues providing additional strength to the cell wall. The integrity of the cell wall is severely compromised without a pentaglycine crosslink, which leads to cell lysis and death. Penicillin G shows MIC₉₀ values of 0.03, 1 and 4 µg/ml for penicillin-susceptible, -intermediate and -resistant strains of S. pneumoniae, respectively. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

Penicillin is a broad-spectrum β-lactam antibiotic. It binds to penicillin binding proteins (PBP). PBP catalyzes the synthesis of peptidoglycan, which is an important component of the bacterial cell wall. PBP catalyzes a pentaglycine crosslink between the alanine and lysine residues providing additional strength to the cell wall. The integrity of the cell wall is severely compromised without a pentaglycine crosslink, which leads to cell lysis and death. Penicillin G shows MIC₉₀ values of 0.03, 1 and 4 µg/ml for penicillin-susceptible, -intermediate and -resistant strains of S. pneumoniae, respectively. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

B3131 | Penicillin G Potassium DataSheet

Alternate Name/Synonyms: Benzylpenicillin potassium; potassium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Appearance: White to off-white powder

Formulation:

CAS Number: 113-98-4

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₁₆H₁₇KN₂O₄S

Molecular Weight: 372.5

Cell-Permeable?: TRUE

Purity: ≥ 98%

Solubilities: ~100 mg/ml in water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A broad-spectrum β-lactam antibiotic

MDL Number: MFCD00036193

PubChem CID: 23664709

SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.[K+]

InChi: InChI=1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

InChi Key: IYNDLOXRXUOGIU-LQDWTQKMSA-M