Penicillin G potassium, USP | 2504

Penicillin G potassium is a member of the β-lactam antibiotics. β-Lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Penicillin can be used as a selective agent in several types of isolation media.

Penicillin G potassium is a member of the β-lactam antibiotics. β-Lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death.

2504 | Penicillin G potassium, USP DataSheet

Alternate Name/Synonyms: Benzylpenicillin potassium salt

Appearance: White to off-white powder

Formulation: N/A

CAS Number: 113-98-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₇KN₂O₄S

Molecular Weight: 372.49

Cell-Permeable?: No

Purity: 1440-1680 u/mg

Solubilities: H₂O (100 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An antibiotic and selection agent

MDL Number: MFCD00036193

PubChem CID: 23664709

SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.[K+]

InChi: InChI=1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

InChi Key: IYNDLOXRXUOGIU-LQDWTQKMSA-M