PER2/Period circadian protein 2 Polyclonal Antibody | BS65878

PER2/Period circadian protein 2 Polyclonal Antibody | BS65878 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Cow,Horse,

Application: IHC-P,

Application Range: IHC-P=1:100-500

Background: PER2, a mammalian homologue of the Drosophila period gene, shares a 40% homology with PER1 including the protein dimerization PAS domain. PER2 is a circadian regulator that may act as a transcription factor. It behaves as a negative element in circadian transcriptional loop. PER2 does not appear to bind DNA, suggesting indirect transcriptional inhibition. Expression oscillates with a 24 hour rhythm in the suprachiasmatic nucleus (SCN) and the whole eyes. Oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. There is a 4 hour time delay between PER1 and PER2 oscillations. The expression rhythms appear to originate from retina.

Storage & Stability: Store at 4°C short term. Aliquot and store at -51°C long term. Avoid freeze-thaw cycles.

Specificity: PER2/Period circadian protein 2 Polyclonal Antibody detects endogenous levels of PER2/Period circadian protein 2 protein.

Molecular Weight: ~138 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Circadian clock protein PERIOD 2; FASPS; hPER 2; hPER2; KIAA0347; PER 2; PER2; Period 2; Period 2 isoform 1; Period circadian protein 2; Period circadian protein homolog 2; Period homolog 2; Period2; FASPS; PER2_HUMAN.

Immunogen: KLH conjugated synthetic peptide derived from human PER2:751-850/1225

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: