Perifosine (KRX-0401) | 1592

Belongs to an alkylphospholipid class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells.

Perifosine (KRX-0401) belongs to an alkylphospholipid class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models.

1592 | Perifosine (KRX-0401) DataSheet

Alternate Name/Synonyms: KRX-0401

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 157716-52-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₅₃NO₄P

Molecular Weight: 462.66

Cell-Permeable?: Yes

Purity: ≥99%

Solubilities: H₂O (10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: An antineoplastic agent

MDL Number: MFCD00927554

PubChem CID: 148178

SMILES: CCCCCCCCCCCCCCCCCCOP(=O)(O)OC1CC[N+](CC1)(C)C

InChi: InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29- 31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3/p+1

InChi Key: SZFPYBIJACMNJV-UHFFFAOYSA-O