Periostin polyclonal Antibody | BS91053

Periostin polyclonal Antibody | BS91053 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB FC

Application Range: WB:1:500-1:2,000 FC:1:50-1:100

Background: Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha (V) beta and alpha (V) beta integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor β 1 (TGF β 1) . Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Periostin polyclonal Antibody detects endogenous levels of Periostin protein.

Molecular Weight: 89 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PN, OSF-2, POSTN, OSF2, Fasciclin-I like, MGC119510, MGC119511, OSF 2, OSF-2, OSF2, Osteoblast specific factor 2 (fasciclin I like), Osteoblast specific factor 2, Osteoblast specific factor, Osteoblast-specific factor 2, PDLPOSTN, Periodontal ligament specific periostin, Periostin, Periostin isoform thy2, Periostin isoform thy4, Periostin isoform thy6, Periostin isoform thy8, Periostin osteoblast specific factor, PN, POSTN, POSTN, RP11 412K4.1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: