PEX5 Antibody | 19-855

PEX5 Antibody | 19-855 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PEX5 (NP_000310.2) .

Research Area: Signal Transduction

Tested Application: WB, IHC, IF

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200

Specificiy: N/A

Positive Control 1: SW480

Positive Control 2: ES-2

Positive Control 3: 293T

Positive Control 4: HepG2

Positive Control 5: MCF7

Positive Control 6: HeLa

Molecular Weight: Observed: 70-85kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: PEX5, peroxisomal biogenesis factor 5, FLJ50634, FLJ50721, FLJ51948, PTS1-BP, PTS1R, PXR1, OTTHUMP00000238192, OTTHUMP00000238193, OTTHUMP00000238194, OTTHUMP00000238195, OTTHUMP00000238353, OTTHUMP00000238354, OTTHUMP00000238356, PTS1 receptor, peroxin-5

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD) , a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD) . Alternatively spliced transcript variants encoding different isoforms have been identified.