PF-03394197 | 2883

PF-03394197 is potent and selective Janus kinase (JAK) inhibitor. It inhibits JAK family members with an IC₅₀ of 10-99 nM being most potent against JAK1 (IC₅₀ = 10 nM). PF-03394197 does not inhibit a panel of 38 non-JAK kinases (IC₅₀ >1 µM). Displays activity against cytokines involved in allergy.

PF-03394197 is potent and selective Janus kinase (JAK) inhibitor. It inhibits JAK family members with an IC₅₀ of 10-99 nM being most potent against JAK1 (IC₅₀ = 10 nM). PF-03394197 does not inhibit a panel of 38 non-JAK kinases (IC₅₀ >1 µM). Displays activity against cytokines involved in allergy.

2883 | PF-03394197 DataSheet

Alternate Name/Synonyms: N-Methyl-1-((1r,4r)-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamide; Oclacitinib

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1208319-26-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₂₃N₅O₂S

Molecular Weight: 337.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective JAK inhibitor

MDL Number: N/A

PubChem CID: 44631938

SMILES: CNS(=O)(=O)CC1CCC(CC1)N(C)C2=NC=NC3=C2C=CN3

InChi: InChI=1S/C15H23N5O2S/c1-16-23(21,22)9-11-3-5-12(6-4-11)20(2)15-13-7-8-17-14(13)18-10-19-15/h7-8,10-12,16H,3-6,9H2,1-2H3,(H,17,18,19)

InChi Key: HJWLJNBZVZDLAQ-UHFFFAOYSA-N