PF-03814735 | B1257

PF-03814735 is an ATP-competitive inhibitor of Aurora kinases A and B with IC₅₀values of 0.8 and 0.5 nM respectively. It has shown to block cytokinesis, inhibit cellular proliferation in many tumor cell lines including HCT-116, HL-60 and A549. In vitro experiments have shown that PF 03814735 inhibits the phosphorylation of Aurora B H3 and Aurora A cultured MDA-MB-231 cells.

PF-03814735 is an ATP-competitive inhibitor of Aurora kinases A and B with IC₅₀values of 0.8 and 0.5 nM respectively. It has shown to block cytokinesis, inhibit cellular proliferation in many tumor cell lines including HCT-116, HL-60 and A549. In vitro experiments have shown that PF 03814735 inhibits the phosphorylation of Aurora B H3 and Aurora A cultured MDA-MB-231 cells.

B1257 | PF-03814735 DataSheet

Alternate Name/Synonyms: N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]-acetamide

Appearance: White solid

Formulation: N/A

CAS Number: 942487-16-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₃H₂₅F₃N₆O₂

Molecular Weight: 474.48

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An ATP-competitive inhibitor of Aurora kinases A and B

MDL Number: N/A

PubChem CID: 49830590

SMILES: CC(=O)NCC(=O)N1C2CCC1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CCC5)C(F)(F)F

InChi: InChI=1S/C23H25F3N6O2/c1-12(33)27-11-20(34)32-18-7-8-19(32)16-9-14(5-6-15(16)18)30-22-28-10-17(23(24,25)26)21(31-22)29-13-3-2-4-13/h5-6,9-10,13,18-19H,2-4,7-8,11H2,1H3,(H,27,33)(H2,28,29,30,31)

InChi Key: RYYNGWLOYLRZLK-UHFFFAOYSA-N