PF-04217903 | B2062

PF-04217903 is a novel ATP-competitive small-molecule inhibitor of c-Met kinase. PF-04217903 displays more than 1,000-fold selectivity for c-Met compared with more than 150 kinases. PF-04217903 inhibits tumor cell proliferation, survival, migration/invasion in MET-amplified cell lines in vitro and shows marked antitumor activity in tumor models harboring either MET gene amplification or a hepatocyte growth factor (HGF)/c-Met autocrine loop at well-tolerated dose levels in vivo.

PF-04217903 is a novel ATP-competitive small-molecule inhibitor of c-Met kinase. PF-04217903 displays more than 1,000-fold selectivity for c-Met compared with more than 150 kinases. PF-04217903 inhibits tumor cell proliferation, survival, migration/invasion in MET-amplified cell lines in vitro and shows marked antitumor activity in tumor models harboring either MET gene amplification or a hepatocyte growth factor (HGF)/c-Met autocrine loop at well-tolerated dose levels in vivo.

B2062 | PF-04217903 DataSheet

Alternate Name/Synonyms: 4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 956905-27-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₆N₈O

Molecular Weight: 372.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A novel ATP-competitive c-Met kinase inhibitor

MDL Number: N/A

PubChem CID: 7754438

SMILES: C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1

InChi: InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2

InChi Key: PDMUGYOXRHVNMO-UHFFFAOYSA-N