PF-04447943 | B1264

PF-04447943 is a potent, brain-penetrant and selective inhibitor of PDE9 (Phosphodiesterase 9) (Ki of 2.8, 4.5 and 18 nM for human, rhesus and rat recombinant PDE9 respectively). Displays high selectivity for PDE9 versus PDEs1-8 and 10-11.

PF-04447943 is a potent, brain-penetrant and selective inhibitor of PDE9 (Phosphodiesterase 9) (Ki of 2.8, 4.5 and 18 nM for human, rhesus and rat recombinant PDE9 respectively). Displays high selectivity for PDE9 versus PDEs1-8 and 10-11.

B1264 | PF-04447943 DataSheet

Alternate Name/Synonyms: N-[2-(diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-Cyclopentapyrimidine-1-acetamide; SB-480848

Appearance: Crystaline solid

Formulation: N/A

CAS Number: 1082744-20-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₀H₂₅N₇O₂

Molecular Weight: 395.46

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, brain-penetrant and selective PDE9 (Phosphodiesterase 9) inhibitor

MDL Number: N/A

PubChem CID: 25115162

SMILES: CC1CN(CC1C2=NC(=O)C3=CNN(C3=N2)C4CCOCC4)CC5=NC=CC=N5

InChi: InChI=1S/C20H25N7O2/c1-13-10-26(12-17-21-5-2-6-22-17)11-16(13)18-24-19-15(20(28)25-18)9-23-27(19)14-3-7-29-8-4-14/h2,5-6,9,13-14,16,23H,3-4,7-8,10-12H2,1H3/t13-,16-/m1/s1

InChi Key: ACXPOEVOYNJCHF-CZUORRHYSA-N