PF-04691502 | 2289

A potent, ATP-competitive PI3K/mTOR dual inhibitor with broad antitumor activity. PF-04691502 potently inhibits recombinant class I PI3K and mTOR in biochemical assays and suppresses transformation of avian fibroblasts mediated by wild-type PI3K γ, δ, or mutant PI3Kα.

PF-04691502 is a potent, ATP-competitive PI3K/mTOR dual inhibitor with broad antitumor activity.

2289 | PF-04691502 DataSheet

Alternate Name/Synonyms: 2-amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1013101-36-4

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₂₂H₂₇N₅O₄

Molecular Weight: 425.48

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent PI3K/mTOR dual inhibitor

MDL Number: N/A

PubChem CID: 25033539

SMILES: CC1=C2C=C(C(=O)N(C2=NC(=N1)N)C3CCC(CC3)OCCO)C4=CN=C(C=C4)OC

InChi: InChI=1S/C22H27N5O4/c1-13-17-11-18(14-3-8-19(30-2)24-12-14)21(29)27(20(17)26-22(23)25-13)15-4-6-16(7-5-15)31-10-9-28/h3,8,11-12,15-16,28H,4-7,9-10H2,1-2H3,(H2,23,25,26)

InChi Key: XDLYKKIQACFMJG-UHFFFAOYSA-N