PF-04965842 | B2470

PF-04965842 (Abrocitinib) is a potent, selective, orally bioavailable JAK1 inhibitor (IC₅₀ = 29 nM). It displays excellent selectivity for JAK1 versus other JAK family enzymes.

PF-04965842 (Abrocitinib) is a potent, selective, orally bioavailable JAK1 inhibitor (IC₅₀ = 29 nM). It displays excellent selectivity for JAK1 versus other JAK family enzymes.

B2470 | PF-04965842 DataSheet

Alternate Name/Synonyms: N-((1s,3s)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide; PF04965842; Abrocitinib

Appearance: Crystalline solid

Formulation:

CAS Number: 1622902-68-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: Yes

Molecular Formula: C₁₄H₂₁N₅O₂S

Molecular Weight: 323.42

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >10 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent Janus Kinase 1 (JAK1) inhibitor

MDL Number:

PubChem CID: 78323835

SMILES: CCCS(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3

InChi: InChI=1S/C14H21N5O2S/c1-3-6-22(20,21)18-10-7-11(8-10)19(2)14-12-4-5-15-13(12)16-9-17-14/h4-5,9-11,18H,3,6-8H2,1-2H3,(H,15,16,17)

InChi Key: IUEWXNHSKRWHDY-UHFFFAOYSA-N