PF-05212384 | 9461

PF-05212384 is a potent, selective and ATP-competitive dual inhibitor of PI 3-kinase/mTOR (IC₅₀ values are 0.4, 1.6 and 5.4 nM for PI 3-Kα, mTOR and PI 3-Kγ respectively). Exhibits selectivity over 234 other protein kinases (IC₅₀ >10 μM). Potently inhibits tumor cell growth in 37 different tumor cell lines (IC₅₀ < 100 nM).

PF-05212384 is a potent, selective and ATP-competitive dual inhibitor of PI 3-kinase/mTOR (IC₅₀ values are 0.4, 1.6 and 5.4 nM for PI 3-Kα, mTOR and PI 3-Kγ respectively). Exhibits selectivity over 234 other protein kinases (IC₅₀ >10 μM). Potently inhibits tumor cell growth in 37 different tumor cell lines (IC₅₀ < 100 nM).

9461 | PF-05212384 DataSheet

Alternate Name/Synonyms: N-[4-[[4-(Dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N'-[4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl]urea; Gedatolisib; PKI-587

Appearance: White solid

Formulation: N/A

CAS Number: 1197160-78-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₃₂H₄₁N₉O₄

Molecular Weight: 615.73

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 3 mg/ml with slight warming)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A dual PI 3-kinase/mTOR inhibitor

MDL Number: N/A

PubChem CID: 44516953

SMILES: CN(C)C1CCN(CC1)C(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCO

InChi: InChI=1S/C32H41N9O4/c1-38(2)27-11-13-39(14-12-27)29(42)24-5-9-26(10-6-24)34-32(43)33-25-7-3-23(4-8-25)28-35-30(40-15-19-44-20-16-40)37-31(36-28)41-17-21-45-22-18-41/h3-10,27H,11-22H2,1-2H3,(H2,33,34,43)

InChi Key: DWZAEMINVBZMHQ-UHFFFAOYSA-N