Description
PF-06821497 is a potent and selective EZH2 (Enhancer of Zeste Homolog 2) inhibitor, inhibiting the activities of both wild-type (Ki = 0.3nM) and mutant (Y641N) (Ki < 0.1nM). Displays robust tumor growth inhibition.
PF-06821497 is a potent and selective EZH2 (Enhancer of Zeste Homolog 2) inhibitor, inhibiting the activities of both wild-type (Ki = 0.3nM) and mutant (Y641N) (Ki < 0.1nM). Displays robust tumor growth inhibition.
Alternate Name/Synonyms: PF06821497 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
Appearance: Solid
Formulation:
CAS Number: 1844849-10-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₄Cl₂N₂O₅
Molecular Weight: 467.34
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent Histone Methyltransferase (HMT) EZH2 inhibitor
MDL Number:
PubChem CID: 118572065
SMILES: COC1=C(CN2CCC(C(Cl)=CC([C@H](OC)C3COC3)=C4Cl)=C4C2=O)C(NC(C)=C1)=O
InChi: InChI=1S/C22H24Cl2N2O5/c1-11-6-17(29-2)15(21(27)25-11)8-26-5-4-13-16(23)7-14(19(24)18(13)22(26)28)20(30-3)12-9-31-10-12/h6-7,12,20H,4-5,8-10H2,1-3H3,(H,25,27)/t20-/m1/s1
InChi Key: RXCVUHMIWHRLDF-HXUWFJFHSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
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