PF-3084014 | B2468

PF-3084014 (Nirogacestat) is a potent and selective gamma-secretase inhibitor (IC₅₀ of 6.2 nM). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.

PF-3084014 (Nirogacestat) is a potent and selective gamma-secretase inhibitor (IC₅₀ of 6.2 nM). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.

B2468 | PF-3084014 DataSheet

Alternate Name/Synonyms: (2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]-pentanamide; Nirogacestat; PF-03084014

Appearance: White solid

Formulation:

CAS Number: 1290543-63-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₄₁F₂N₅O

Molecular Weight: 489.6

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >40 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A reversible, noncompetitive, and selective γ-secretase inhibitor

MDL Number:

PubChem CID: 46224413

SMILES: CCCC(C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)NC2CCC3=CC(=CC(=C3C2)F)F

InChi: InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1

InChi Key: FCRKLWBYMDAED-REWPJTCUSA-N