PF-431396 | 2844

PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor with IC₅₀ values 2 and 11 nM respectively.

PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor with IC₅₀ values 2 and 11 nM respectively.

2844 | PF-431396 DataSheet

Alternate Name/Synonyms: N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 717906-29-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₁F₃N₆O₃S

Molecular Weight: 506.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor

MDL Number: MFCD21608515

PubChem CID: 11598628

SMILES: CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C

InChi: InChI=1S/C22H21F3N6O3S/c1-31(35(2,33)34)18-6-4-3-5-13(18)11-26-20-16(22(23,24)25)12-27-21(30-20)28-15-7-8-17-14(9-15)10-19(32)29-17/h3-9,12H,10-11H2,1-2H3,(H,29,32)(H2,26,27,28,30)

InChi Key: POJZIZBONPAWIV-UHFFFAOYSA-N