PF-670462 | B2271

PF-670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC₅₀ values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other kinases. Inhibits PER protein nuclear translocation (EC₅₀ = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.

PF-670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC₅₀ values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other kinases. Inhibits PER protein nuclear translocation (EC₅₀ = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.

B2271 | PF-670462 DataSheet

Alternate Name/Synonyms: 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride

Appearance: Off-white solid

Formulation: N/A

CAS Number: 950912-80-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₀FN₅.2HCl

Molecular Weight: 410.32

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>35 mg/ml) or H2O (>35 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor

MDL Number: N/A

PubChem CID: 51049607

SMILES: C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl

InChi: InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H

InChi Key: PSNKGVAXBSAHCH-UHFFFAOYSA-N