PF-8380 | B1927

PF-8380 is a potent and specific inhibitor of Autotaxin (ATX) (IC₅₀ = 2.8 nM). Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin. Autotaxin (ATX) is a secreted enzyme having lysophospholipase D activity.

PF-8380 is a potent and specific inhibitor of Autotaxin (ATX) (IC₅₀ = 2.8 nM). Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin. Autotaxin (ATX) is a secreted enzyme having lysophospholipase D activity.

B1927 | PF-8380 DataSheet

Alternate Name/Synonyms: 3,5-dichlorobenzyl4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1144035-53-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₁Cl₂N₃O₅

Molecular Weight: 478.33

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent autotaxin inhibitor

MDL Number: N/A

PubChem CID: 25265312

SMILES: C1CN(CCN1CCC(=O)C2=CC3=C(C=C2)NC(=O)O3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl

InChi: InChI=1S/C22H21Cl2N3O5/c23-16-9-14(10-17(24)12-16)13-31-22(30)27-7-5-26(6-8-27)4-3-19(28)15-1-2-18-20(11-15)32-21(29)25-18/h1-2,9-12H,3-8,13H2,(H,25,29)

InChi Key: JMSUDQYHPSNBSN-UHFFFAOYSA-N