PF-9366 | B2244

PF-9366 is an allosteric inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform (IC₅₀ = 420 nM). PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC₅₀ of 1.2 μM in H520 lung carcinoma cells.

PF-9366 is an allosteric inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform (IC₅₀ = 420 nM). PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC₅₀ of 1.2 μM in H520 lung carcinoma cells.

B2244 | PF-9366 DataSheet

Alternate Name/Synonyms: 2-(7-Chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 72882-78-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₉ClN₄

Molecular Weight: 350.85

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An allosteric human methionine adenosyltransferase 2A (Mat2A) inhibitor

MDL Number: N/A

PubChem CID: 12612431

SMILES: CN(C)CCC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=C2)C4=CC=CC=C4

InChi: InChI=1S/C20H19ClN4/c1-24(2)11-10-19-22-23-20-13-16(14-6-4-3-5-7-14)17-12-15(21)8-9-18(17)25(19)20/h3-9,12-13H,10-11H2,1-2H3

InChi Key: LYLASWLQCMKZAT-UHFFFAOYSA-N