PFI-1 | 2203

PFI-1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. In an AlphaScreen assay it has been shown to inhibit BRD2 bromodomain 2 and BRD4 bromodomain 1 with IC₅₀ values of 98 nM and 0.22 μM, respectively.

PFI-1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. In an AlphaScreen assay it has been shown to inhibit BRD2 bromodomain 2 and BRD4 bromodomain 1 with IC₅₀ values of 98 nM and 0.22 μM, respectively.

2203 | PFI-1 DataSheet

Alternate Name/Synonyms: 2-​Methoxy-​N-​(3-​methyl-​2-​oxo-​1,​2,​3,​4-​tetrahydroquinazolin-​6-​yl)benzenesulfonamide

Appearance: Beige solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₇N₃O₄S

Molecular Weight: 347.39

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (50 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent BET bromodomain inhibitor

MDL Number: MFCD22580416

PubChem CID: 71271629

SMILES: CN1CC2=C(C=CC(=C2)NS(=O)(=O)C3=CC=CC=C3OC)NC1=O

InChi: InChI=1S/C16H17N3O4S/c1-19-10-11-9-12(7-8-13(11)17-16(19)20)18-24(21,22)15-6-4-3-5-14(15)23-2/h3-9,18H,10H2,1-2H3,(H,17,20)

InChi Key: TXZPMHLMPKIUGK-UHFFFAOYSA-N