PFI-4 | B2330

PFI-4 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Displays >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. BRPF1 is important for maintaining Hox gene expression and the development of multiple tissues, axial skeleton, and the hematopoietic system.

PFI-4 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Displays >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.

B2330 | PFI-4 DataSheet

Alternate Name/Synonyms: N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide

Appearance: Pale green solid

Formulation:

CAS Number: 900305-37-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₁H₂₄N₄O₃

Molecular Weight: 380.44

Cell-Permeable?: Yes

Purity: ≥ by HPLC

Solubilities: >15 mg/ml (DMSO) in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective BRPF1 bromodomain inhibitor

MDL Number:

PubChem CID: 40642506

SMILES: CN1C2=CC(=C(C=C2N(C1=O)C)N3CCCC3)NC(=O)C4=CC=CC=C4OC

InChi: InChI=1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26)

InChi Key: QCIJLRJBZDBVDB-UHFFFAOYSA-N