PHA-680632 | B1944

PHA-680632 is potent inhibitor of Aurora kinases A, B, and C with IC₅₀ values of of 27 nM, 135 nM and 120 nM, respectively. It displays weaker selectivity for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.

PHA-680632 is potent inhibitor of Aurora kinases A, B, and C with IC₅₀ values of of 27 nM, 135 nM and 120 nM, respectively. It displays weaker selectivity for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.

B1944 | PHA-680632 DataSheet

Alternate Name/Synonyms: N-(2,6-diethylphenyl)-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 398493-79-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₃₅N₇O₂

Molecular Weight: 501.62

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>35 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of Aurora kinases A, B, and C

MDL Number: N/A

PubChem CID: 11249084

SMILES: CCC1=C(C(=CC=C1)CC)NC(=O)N2CC3=C(C2)NN=C3NC(=O)C4=CC=C(C=C4)N5CCN(CC5)C

InChi: InChI=1S/C28H35N7O2/c1-4-19-7-6-8-20(5-2)25(19)29-28(37)35-17-23-24(18-35)31-32-26(23)30-27(36)21-9-11-22(12-10-21)34-15-13-33(3)14-16-34/h6-12H,4-5,13-18H2,1-3H3,(H,29,37)(H2,30,31,32,36)

InChi Key: OBWNXGOQPLDDPS-UHFFFAOYSA-N