PHF3 (D2033) polyclonal Antibody | BS9156

PHF3 (D2033) polyclonal Antibody | BS9156 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: PHF3 (PHD finger protein 3) is a 2039 amino acid ubiquitously expressed protein that is phosphorylated upon DNA damage by either ATM or ATR. PHF3 contains a PHD finger motif, a proline-rich region, a TFIIS domain and two bipartite nuclear localization signals. Since these motifs are frequently found in proteins involved in transcription, PHF3 may function as a transcription factor. Expression of PHF3 is significantly reduced in anaplastic astrocytomas, glioblastomas and glioblastoma cell lines, suggesting that PHF3 plays a role as a tumor suppressor. Antibodies against PHF3 are present in some patients afflicted with glioblastoma multiforme and presence of the, correlates to significantly better survival rates. There are two isoforms of PHF3 that are produced as a result of alternative splicing events.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PHF3 (D2033) polyclonal Antibody detects endogenous levels of PHF3 protein.

Molecular Weight: ~ 229 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PHD finger protein 3; PHF3; PHF3;

Immunogen: Synthetic peptide, corresponding to the C-terminus of Human PHF3.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: