PHLPP1 polyclonal Antibody | BS60440

PHLPP1 polyclonal Antibody | BS60440 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: SCOP (Suprachiasmatic nucleus circadian oscillatory protein, PHLPP, PH domain and leucine rich repeat protein phosphatase, PLEKHE1) is a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Endogenous SCOP in human embryonic kidney cell lysates produces a major protein and minor protein. SCOP negatively regulates K-Ras signaling in membrane rafts and contributes to the regulation of the Ras-MAPK signaling pathway. Recombinant SCOP can dephosphorylate the hydrophobic motif of Akt1 (ser-473) in vitro, triggering apoptosis and suppressing tumor growth. SCOP levels appear lower in certain colon cancer and glioblastoma cell lines that show elevated Akt phosphorylation. Rat tissues that express SCOP include cerebrum, cerebellum, and testis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PHLPP1 polyclonal Antibody detects endogenous levels of PHLPP1 protein.

Molecular Weight: ~ 171 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PH domain leucine-rich repeat-containing protein phosphatase 1; Pleckstrin homology domain-containing family E member 1; PH domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein; hSCOP; PHLPP1; KIAA0606; PHLPP; PLEKHE1; SCOP

Immunogen: A synthetic peptide corresponding to residues in Human PHLPP1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: