LBD
Phospho-CDX2 (S283) Antibody [APR05228G]
- SKU:
- LBD-APR05228G
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- Usually ships in 5 working days
Description
Phospho-CDX2 (S283) Antibody [APR05228G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This CDX2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S283 of human CDX2.
Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:P43241}.
Molecular Weight: 33520
Clone: Polyclonal
Gene Name: CDX2
Gene ID: 1045
Function: Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity) . Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity) . Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity) . Binds to and activates transcription of LPH (By similarity) . Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity) . Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity) . Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536) .
Summary: Tissue Location: Detected in small intestine, colon and pancreas.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IF, DB
Dilution: IF--1:10~50 DB--1:500
Synonyms: Homeobox protein CDX-2, CDX-3, Caudal-type homeobox protein 2, CDX2, CDX3