Phospho-MAP4K1 (S171) Antibody [AMM07145G]

Phospho-MAP4K1 (S171) Antibody [AMM07145G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This MAP4K1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S171 of human MAP4K1.

Cellular Localisation: N/A

Molecular Weight: 91296

Clone: Polyclonal

Gene Name: MAP4K1

Gene ID: 11184

Function: Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026) . Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585) . May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026) . Able to autophosphorylate (PubMed:8824585) . Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity) .

Summary: Tissue Location: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Mitogen-activated protein kinase kinase kinase kinase 1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, MAP4K1, HPK1