phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody | BS65621

phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody | BS65621 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,

Application: IHC-P,

Application Range: IHC-P=1:100-500

Background: p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody detects endogenous levels of phospho-p53BP1 protein only when phosphorylated at Ser25 + Ser29.

Molecular Weight: 213kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: 53BP1 (phospho S25) ; p-53BP1 (phospho S25) ;53BP1 (Phospho-Ser25/29) ; 53BP1 (Phospho-S25/S29) ; phospho-p53BP1 (Ser25/Ser29) ; P-53BP1 (Ser25/29) ; 53 BP1; FLJ41424; MGC138366; p202; p53 binding protein 1; p53 BP1; p53BP1; TP53 BP1; TP53BP1; Tumor protein 53 binding protein 1; Tumor protein p53 binding protein 1; Tumor suppressor p53 binding protein 1; TP53B_HUMAN; tumor protein 53-binding protein, 1.

Immunogen: KLH conjugated Synthesised phosphopeptide derived from human p53BP1 around the phosphorylation site of Ser25/29:ED (p-S) QPE (p-S) QV

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: affinity purified by Protein A

Pathway: