Phospho-PIM1 (Tyr309) Polyclonal Antibody | BS65627

Phospho-PIM1 (Tyr309) Polyclonal Antibody | BS65627 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep,

Application: FCM,

Application Range: Flow-Cyt=1ug/Test

Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810) .[provided by RefSeq, Aug 2011].

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Phospho-PIM1 (Tyr309) Polyclonal Antibody detects endogenous levels of Phospho-PIM1 protein only when phosphorylated at Tyr309

Molecular Weight: 45kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PIM1 (phospho Y309) ; PIM1 (phospho Tyr309) ; Oncogene PIM 1; Oncogene PIM1; PIM 1; Pim 1 kinase; Pim 1 oncogene; PIM; Pim2; PIM3; Proto oncogene serine/threonine protein kinase Pim 1; Proviral integration site 1; Proviral integration site 2

Immunogen: KLH conjugated Synthesised phosphopeptide derived from human PIM1 around the phosphorylation site of Tyr309

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: affinity purified by Protein A

Pathway: