Phospho-rat TSC1 (T417) Antibody [APR32078G]

Phospho-rat TSC1 (T417) Antibody [APR32078G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: Rat

Specificity: This rat TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T417 of rat TSC1.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:Q92574}. Membrane {ECO:0000250|UniProtKB:Q92574}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q92574}. Note=At steady state found in association with membranes. {ECO:0000250|UniProtKB:Q92574}

Molecular Weight: 129022

Clone: Polyclonal

Gene Name: Tsc1

Gene ID: 60445

Function: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity) . Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (PubMed:16707451) . Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (By similarity) . Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (By similarity) . Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity) . Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (By similarity) .

Summary: Tissue Location: Highly expressed in brain, spleen and kidney, followed by liver and heart

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: DB

Dilution: DB--1:500

Synonyms: Hamartin, Tuberous sclerosis 1 protein homolog, Tsc1