Phospho-rat TSC2 (T1373) Antibody [APR05316G]

Phospho-rat TSC2 (T1373) Antibody [APR05316G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: Rat

Specificity: This rat TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T1373 of rat TSC2.

Cellular Localisation: N/A

Molecular Weight: 201278

Clone: Polyclonal

Gene Name: Tsc2

Gene ID: 24855

Function: In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity) . Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity) . May also play a role in microtubule-mediated protein transport (PubMed:16707451) . Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (PubMed:9045618) .

Summary: Tissue Location: CNS, uterus, heart, skeletal muscle, kidney and spleen

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: DB

Dilution: DB--1:500

Synonyms: Tuberin, Tuberous sclerosis 2 protein homolog, Tsc2