Phospho-Rb(S811) Polyclonal Antibody | E-AB-68083

Phospho-Rb(S811) Polyclonal Antibody | E-AB-68083 | Gentaur UK, US & Europe Distribution

Type: Phosphorylated antibody

Synonyms: OSRC, PPP1R130, RB, p105-Rb, pRb, pp110, RB1, Rb

Application: WB, IF

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A synthetic phosphorylated peptide around S811 of human Rb (NP_000312.2).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:1000-1:2000 IF 1:50-1:100

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 106 kDa

Molecular Weight(Observed): 106 kDa