Phospho-Sox2 (S249) Antibody [APR12843G]

Phospho-Sox2 (S249) Antibody [APR12843G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This Sox2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S249 of human Sox2.

Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:P48432}.

Molecular Weight: 34310

Clone: Polyclonal

Gene Name: SOX2

Gene ID: 6657

Function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity) . Binds to the proximal enhancer region of NANOG (By similarity) . Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408) . Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity) . Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) . May function as a switch in neuronal development (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: DB

Dilution: DB--1:500

Synonyms: Transcription factor SOX-2, SOX2