PI-103 | 1728

A cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. The IC₅₀ values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively. Inhibits growth of human tumor xenografts in mice in vivo.

PI-103 is a cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. The IC₅₀ values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively. Inhibits growth of human tumor xenografts in mice in vivo.

1728 | PI-103 DataSheet

Alternate Name/Synonyms: 3-(4-(4-Morpholinyl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenol

Appearance: Off-white solid

Formulation: N/A

CAS Number: 371935-74-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₆N₄O₃

Molecular Weight: 348.36

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (50 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A PI3 Kinase inhibitor

MDL Number: MFCD11983145

PubChem CID: 9884685

SMILES: C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O

InChi: InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2

InChi Key: TUVCWJQQGGETHL-UHFFFAOYSA-N