PI3-Kɣ Inhibitor, AS-605240 | 1780

Cell-permeable. A potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC₅₀ = 8 nM). Displays >33-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα.

AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC₅₀ = 8 nM). Displays >33-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα.

1780 | PI3-Kɣ Inhibitor, AS-605240 DataSheet

Alternate Name/Synonyms: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione

Appearance: Pink to reddish solid

Formulation: N/A

CAS Number: 648450-29-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₇N₃O₂S

Molecular Weight: 257.27

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO ( 1 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of PI 3-kinase γ (PI3Kγ)

MDL Number: MFCD11100415

PubChem CID: 5289247

SMILES: C1=CC2=NC=CN=C2C=C1C=C3C(=O)NC(=O)S3

InChi: InChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6-

InChi Key: SQWZFLMPDUSYGV-POHAHGRESA-N