PI3K p110α polyclonal Antibody | BS91070

PI3K p110α polyclonal Antibody | BS91070 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC/IF IP

Application Range: WB:1:500-1:1,000 ICC:1:50-1:200

Background: Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110δ expression is restricted to white blood cells. It has been shown to bind p85α and β, but it apparently does not phosphorylate these subunits. p110δ seems to have the capacity to autophosphorylate. p110γ does not interact with the p85 subunits. It has been shown to be activated by α and βγ heterotrimeric G proteins.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PI3K p110α polyclonal Antibody detects endogenous levels of PI3K p110α protein.

Molecular Weight: 124 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PI3-kinase subunit alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase subunit alpha, PtdIns-3-kinase subunit p110-alpha, p110alpha, PIK3CA, 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, 5-bisphosphate 3-kinase catalytic subunit alpha isoform, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, MGC142161, MGC142163, p110 alpha, p110alpha, Phosphatidylinositol 3 kinase catalytic alpha polypeptide, Phosphatidylinositol 3 kinase catalytic 110 KD alpha, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform, Phosphatidylinositol 4, 5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha, Phosphatidylinositol-4, Phosphoinositide 3 kinase catalytic alpha polypeptide, PI3 kinase p110 subunit alpha, PI3-kinase subunit alpha, PI3K, PI3K-alpha, PI3KC A, PIK3C A, Pik3ca, PK3CA, PK3CA, PtdIns 3 kinase p110, PtdIns-3-kinase subunit alpha, PtdIns-3-kinase subunit p110-alpha, Serine/threonine protein kinase PIK3CA,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: