PIBF1 Antibody | 7237

PIBF1 Antibody | 7237 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Rabbit polyclonal PIBF1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human PIBF1.
The immunogen is located within amino acids 610 - 660 of PIBF1.

Research Area: Signal Transduction

Tested Application: E, WB, IHC-P, IF

Application: PIBF1 antibody can be used for detection of PIBF1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: Multiple isoforms of PIBF1 exists as a result of alternative splicing event.

Positive Control 1: Cat. No. 1309 - Human Placenta Tissue Lysate

Positive Control 2: Cat. No. 10-901 - Human Spleen Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 83 kDa

Validation: N/A

Isoform: N/A

Purification: PIBF1 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PIBF1 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: PIBF1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: PIBF1 Antibody: PIBF, CEP90, C13orf24, PIBF, Progesterone-induced-blocking factor 1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: PIBF1 Antibody: PIBF1 is synthesized during pregnancy in response to progesterone by T lymphocytes. PIBF1 inhibits arachidonic acid release, controls NK activity, and modifies the cytokine balance exerting an anti-abortive effect. It contains a leucine zipper motif, a basic zipper sequence, a PEST sequence, a nuclear localization signal, an ER membrane retention signal and N-glycosylation and phosphorylation sites. PIBF1 is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. Full-length PIBF1 is associated with the nucleus and functions as a transcription factor, whereas secretion of shorter forms which may act as cytokines is induced by activation of the cell.