PIDD Antibody | 36-329

PIDD Antibody | 36-329 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: Recombinant human PIDD (Death Domain: aa 776-910) .

Research Area: Apoptosis, Cancer, Innate Immunity

Tested Application: IHC, IP, WB

Application: Immunohistochemistry: (paraffin sections) . Immunoprecipitation: (1:100) . Western Blot: (1:500) .

Specificiy: Recognizes human and the native form of mouse PIDD. Detects bands of ~90kDa (full length protein) and ~50kDa (cleaved protein) by Western blot.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage Condition: Stable for at least 1 year after receipt when stored at -20˚C.

Alternate Name: p53-induced Protein with a Death Domain; Leucine-rich Repeat and Death Domain-containing Protein; Lrdd

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.