Pidotimod | B2701

Pidotimod is a synthetic dipeptide with immunomodulatory properties. Pidotimod inhibits tumor necrosis factor α (TNF-α) induced increases in extracellular signal-related kinase (ERK) phosphorylation. It also increases nuclear factor-κB (NF-κB) expression and translocation to the nucleus. It is these to modulatory effects on ERK and NF-κB signaling which are thought to produce the increase in toll-like receptor expression seen with pidotimod.

Pidotimod is a synthetic dipeptide with immunomodulatory properties. Pidotimod inhibits tumor necrosis factor α (TNF-α) induced increases in extracellular signal-related kinase (ERK) phosphorylation. It also increases nuclear factor-κB (NF-κB) expression and translocation to the nucleus. It is these to modulatory effects on ERK and NF-κB signaling which are thought to produce the increase in toll-like receptor expression seen with pidotimod.

B2701 | Pidotimod DataSheet

Alternate Name/Synonyms: PGT/1A,3-[[(2S)-5-oxo-2-pyrrolidinyl]carbonyl]-4R-thiazolidinecarboxylic acid

Appearance: White to off-white solid

Formulation:

CAS Number: 121808-62-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₉H₁₂N₂O₄S

Molecular Weight: 244.27

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~ 5 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A tumor necrosis factor α (TNF-α) inhibitor

MDL Number: MFCD00867583

PubChem CID: 65944

SMILES: O=C1CC[C@@H](C(N2[C@H](C(O)=O)CSC2)=O)N1

InChi: InChI=1S/C9H12N2O4S/c12-7-2-1-5(10-7)8(13)11-4-16-3-6(11)9(14)15/h5-6H,1-4H2,(H,10,12)(H,14,15)/t5-,6-/m0/s1

InChi Key: UUTKICFRNVKFRG-WDSKDSINSA-N