PIH1D1 Antibody (Center) [APR31864G]

PIH1D1 Antibody (Center) [APR31864G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PIH1D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-192 amino acids from the Central region of human PIH1D1.

Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:Q9CQJ2}.

Molecular Weight: 32363

Clone: Polyclonal

Gene Name: PIH1D1

Gene ID: 55011

Function: Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026) . Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription (PubMed:22368283, PubMed:24036451) . Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032) . Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451) .

Summary: Tissue Location: Expressed at low levels in normal mammary epithelial cells (at protein level) (PubMed:24036451) . Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen, testis and thymus (PubMed:21078300)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: PIH1 domain-containing protein 1, Nucleolar protein 17 homolog, PIH1D1, NOP17