PIH1D1 polyclonal Antibody | BS72137

PIH1D1 polyclonal Antibody | BS72137 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Nop17 (nucleolar protein 17), also known as PIH1D1, is a phylogenetically conserved protein essential for efficient processing of pre-rRNA through its association with a class of small nucleolar RNAs (snoRNAs) during ribosomal biogenesis. SnoRNAs are associated in ribonucleoprotein particles localized to the nucleolus. Nop17 is a 290 amnio acid unstable protein that is stabilized through an interaction with HSP 90α/β. Nop17 interacts with a core box C/D snoRNP protein Nop58, indicating a function of Nop17 in mediating the nucleolar retention or proper assembly of the box C/D snoRNP. A mutation in NOP17 gene may lead to a temperature-sensitive phenotype along with delocalization of key Nop proteins that are essential for snoRNP assembly.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PIH1D1 polyclonal Antibody detects endogenous levels of PIH1D1 protein.

Molecular Weight: 38kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NOP17

Immunogen: Recombinant protein of human PIH1D1

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: