PIK-294 | 2614

PIK-294 is a highly potent and selective p110δ inhibitor (IC₅₀ of 10 nM). Displays 1000-, 49- and 16-fold less potency against PI3Kα/β/γ, respectively.

PIK-294 is a highly potent and selective p110δ inhibitor (IC₅₀ of 10 nM). Displays 1000-, 49- and 16-fold less potency against PI3Kα/β/γ, respectively.

2614 | PIK-294 DataSheet

Alternate Name/Synonyms: 2-[[4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 900185-02-6

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₂₃N₇O₂

Molecular Weight: 489.53

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO (>60 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent PI3K p110δ inhibitor

MDL Number: N/A

PubChem CID: 24905149

SMILES: O=C1N(C2=CC=CC=C2C)C(CN3N=C(C4=CC=CC(O)=C4)C5=C(N)N=CN=C53)=NC6=C1C(C)=CC=C6

InChi: InChI=1S/C28H23N7O2/c1-16-7-3-4-12-21(16)35-22(32-20-11-5-8-17(2)23(20)28(35)37)14-34-27-24(26(29)30-15-31-27)25(33-34)18-9-6-10-19(36)13-18/h3-13,15,36H,14H2,1-2H3,(H2,29,30,31)

InChi Key: WFSLJOPRIJSOJR-UHFFFAOYSA-N