PIK3C2B monoclonal Antibody | MB64490

PIK3C2B monoclonal Antibody | MB64490 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: IF, IHC, WB

Application Range: WB 1:2000~4000, IHC 1:150, IF 1:100

Background: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta

Molecular Weight: 184.7 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: C2-PI3K

Immunogen: Full length human recombinant protein of human PIK3C2B (NP_002637) produced in HEK293T cell.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A