Pinocembrin | B3289

Pinocembrin is a natural product isolated from the leaves of A. zerumbet. It displays enhanced alkaline phosphatase (ALP) activity and mineralization and increased mRNA expression of osteoblast-related genes Alp and Osteocalcin (Ocn) in MC3T3-E1 cells. Pinocembrin increases the mRNA expression of Runx2 and Osterix, which are important transcription factors in osteoblast differentiation, and the mRNA expression of Dlx5 and Msx2, which are enhancers of these transcription factors. Pinocembrin induces ER stress mediated apoptosis and suppress autophagy in melanoma, indicating its application potential for melanoma therapy.

Pinocembrin is a natural product isolated from the leaves of A. zerumbet. It displays enhanced alkaline phosphatase (ALP) activity and mineralization and increased mRNA expression of osteoblast-related genes Alp and Osteocalcin (Ocn) in MC3T3-E1 cells. Pinocembrin increases the mRNA expression of Runx2 and Osterix, which are important transcription factors in osteoblast differentiation, and the mRNA expression of Dlx5 and Msx2, which are enhancers of these transcription factors. Pinocembrin induces ER stress mediated apoptosis and suppress autophagy in melanoma, indicating its application potential for melanoma therapy.

B3289 | Pinocembrin DataSheet

Alternate Name/Synonyms: 5,7-dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one Dihydrochrysin NSC 279005

Appearance: White to yellow solid

Formulation:

CAS Number: 480-39-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₂O₄

Molecular Weight: 256.25

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: ~30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A biologically active natural product

MDL Number:

PubChem CID: 68071

SMILES: C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=CC=C3

InChi: InChI=1S/C15H12O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-7,13,16-17H,8H2/t13-/m0/s1

InChi Key: URFCJEUYXNAHFI-ZDUSSCGKSA-N