Description
Pinocembrin is a natural product isolated from the leaves of A. zerumbet. It displays enhanced alkaline phosphatase (ALP) activity and mineralization and increased mRNA expression of osteoblast-related genes Alp and Osteocalcin (Ocn) in MC3T3-E1 cells. Pinocembrin increases the mRNA expression of Runx2 and Osterix, which are important transcription factors in osteoblast differentiation, and the mRNA expression of Dlx5 and Msx2, which are enhancers of these transcription factors. Pinocembrin induces ER stress mediated apoptosis and suppress autophagy in melanoma, indicating its application potential for melanoma therapy.
Pinocembrin is a natural product isolated from the leaves of A. zerumbet. It displays enhanced alkaline phosphatase (ALP) activity and mineralization and increased mRNA expression of osteoblast-related genes Alp and Osteocalcin (Ocn) in MC3T3-E1 cells. Pinocembrin increases the mRNA expression of Runx2 and Osterix, which are important transcription factors in osteoblast differentiation, and the mRNA expression of Dlx5 and Msx2, which are enhancers of these transcription factors. Pinocembrin induces ER stress mediated apoptosis and suppress autophagy in melanoma, indicating its application potential for melanoma therapy.
Alternate Name/Synonyms: 5,7-dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one Dihydrochrysin NSC 279005
Appearance: White to yellow solid
Formulation:
CAS Number: 480-39-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₁₂O₄
Molecular Weight: 256.25
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: ~30 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A biologically active natural product
MDL Number:
PubChem CID: 68071
SMILES: C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=CC=C3
InChi: InChI=1S/C15H12O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-7,13,16-17H,8H2/t13-/m0/s1
InChi Key: URFCJEUYXNAHFI-ZDUSSCGKSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |