Piperine | B2086

Piperine is the primary pungent alkaloid isolated from the fruit of black peppercorns. It displays a variety of therapeutic activities such as anti-oxidant, anti-inflammatory, immunomodulatory, anti-asthmatic, anti-convulsant, anti-mutagenic, antimycobacterial, anti-amoebic, and anti-cancer activities. Piperine affects cytochrome P450 (CYP) isoforms, inhibiting CYP3A species (Ki ~ 5 µM) and increasing expression of CYP1A and CYP2B in liver. It also has a biphasic effect on P-glycoprotein activity.

Piperine is the primary pungent alkaloid isolated from the fruit of black peppercorns. It displays a variety of therapeutic activities such as anti-oxidant, anti-inflammatory, immunomodulatory, anti-asthmatic, anti-convulsant, anti-mutagenic, antimycobacterial, anti-amoebic, and anti-cancer activities

B2086 | Piperine DataSheet

Alternate Name/Synonyms: (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-2,4-pentadien-1-one; N-Piperoylpiperidin; NSC 21727; Bioperine

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 94-62-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₉NO₃

Molecular Weight: 285.354

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent antioxidant and antiinflammatory agent

MDL Number: MFCD00005839

PubChem CID: 638024

SMILES: C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3

InChi: InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+

InChi Key: MXXWOMGUGJBKIW-YPCIICBESA-N