Piperlonguminine | 1988

Piperlonguminine is a known alkaloid amide from peppers, including Piper divaricatum. Acts as a potent anticancer agent. Displays inhibitory effect on alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanogenesis in melanoma B16 cells (IC₅₀= 9.6 µM). The mode of action is through the inhibition of alpha-MSH-induced tyrosinase synthesis.

Piperlonguminine is a known alkaloid amide from peppers, including Piper divaricatum. Acts as a potent anticancer agent. Displays inhibitory effect on alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanogenesis in melanoma B16 cells (IC₅₀= 9.6 µM). The mode of action is through the inhibition of alpha-MSH-induced tyrosinase synthesis.

1988 | Piperlonguminine DataSheet

Alternate Name/Synonyms: (2E, 4E)-5-(Benzo[d][1,3]-dioxol-5-yl)-N-isobutylpenta-2,4-dienamide

Appearance: White solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₉NO₃

Molecular Weight: 273.33

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from light and air

Country of Origin: USA

Tag Line: An anticancer agent

MDL Number: N/A

PubChem CID: 5320621

SMILES: CC(C)CNC(=O)C=CC=CC1=CC2=C(C=C1)OCO2

InChi: InChI=1S/C16H19NO3/c1-12(2)10-17-16(18)6-4-3-5-13-7-8-14-15(9-13)20-11- 19-14/h3-9,12H,10-11H2,1-2H3,(H,17,18)/b5-3+,6-4+

InChi Key: WHAAPCGHVWVUEX-GGWOSOGESA-N