LBD
PITRM1 Antibody (Center) [APR03686G]
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- LBD-APR03686G
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Description
PITRM1 Antibody (Center) [APR03686G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This PITRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the Central region of human PITRM1.
Cellular Localisation: Mitochondrion matrix
Molecular Weight: 117413
Clone: Polyclonal
Gene Name: PITRM1 (HGNC:17663)
Gene ID: 10531
Function: Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469) . Has an ATP-independent activity (PubMed:16849325) . Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155) . Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469) . Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155) . Also degrades other unstructured peptides (PubMed:19196155) . It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469) . It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469) . Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469) .
Summary: Tissue Location: Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Presequence protease, mitochondrial, hPreP, 3424-, Pitrilysin metalloproteinase 1, Metalloprotease 1, hMP1, PITRM1, KIAA1104, MP1