PJVK Antibody (Center) [APR14242G]

PJVK Antibody (Center) [APR14242G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PJVK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-197 amino acids from the Central region of human PJVK.

Cellular Localisation: Peroxisome membrane {ECO:0000250|UniProtKB:Q0ZLH2}. Cell projection, cilium {ECO:0000250|UniProtKB:Q0ZLH2}. Note=Associates with the peroxisomal membrane; it is unclear whether it is embedded or just associated with the peroxisomal membrane. Localizes to ciliary rootlet {ECO:0000250|UniProtKB:Q0ZLH2}

Molecular Weight: 39913

Clone: Polyclonal

Gene Name: PJVK {ECO:0000303|PubMed:16804542, ECO:0000312|HGNC:HGNC:29502}

Gene ID: 494513

Function: Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise- induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy) . Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Pejvakin, Autosomal recessive deafness type 59 protein, DFNB59, PJVK