PKA 2β polyclonal Antibody | BS91078

PKA 2β polyclonal Antibody | BS91078 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IP ICC/IF IHC FC

Application Range: WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: The second messenger cyclic AMP mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA) . Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. One of several regulatory subunits, p-PKA IIβ reg (cAMP-dependent protein kinase type II-beta regulatory subunit), also known as PRKAR2B, is a 418 amino acid protein that is phosphorylated by the activated catalytic chain. p-PKA IIβ reg knockout mice exhibit diminished white adipose tissue and were protected against diet-induced obesity and fatty livers,as well as markedly reduced leptin mRNA. Also playing a role in the immune response, p-PKA IIβ reg suppresses CREB transcriptional activity and down-regulates IL-2 production in T-lymphocytes.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PKA 2β polyclonal Antibody detects endogenous levels of PKA 2β protein.

Molecular Weight: 46 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PRKAR2B, AI451071, AW061005, cAMP dependent protein kinase type II beta regulatory chain, cAMP dependent protein kinase type II beta regulatory subunit, cAMP-dependent protein kinase type II-beta regulatory subunit, H RG363E19.2, KAP3, MGC116401, Pkarb2, PRKAR 2, PRKAR2, PRKAR2B, Protein kinase cAMP dependent regulatory type II beta, RATDNA, RII beta, RII (beta), RIIbeta, WUGSC:H RG363E19.2,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: