PKA Cα polyclonal Antibody | BS91079

PKA Cα polyclonal Antibody | BS91079 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: ICC IHC FC

Application Range: ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA) . Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Cα, Cβ and Cγ, that each represent specific gene products. Cα and Cβ are closely related (93% amino acid sequence similarity), whereas Cγ displays 83% and 79% similarity to Cα and Cβ, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the pol II transcription initiation complex.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PKA Cα polyclonal Antibody detects endogenous levels of PKA Cα protein.

Molecular Weight: 40 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PKA C-alpha, PRKACA, PKACA, cAMP dependent protein kinase beta catalytic subunit, cAMP dependent protein kinase alpha catalytic subunit, cAMP dependent protein kinase catalytic subunit alpha, cAMP dependent protein kinase catalytic subunit beta, PKA C alpha, PKA C beta, PKACA, PKACB, PRKACA, PRKACB, Protein kinase cAMP dependent catalytic alpha, Protein kinase cAMP dependent catalytic beta,

Immunogen: Recombinant protein.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein affinity purified.

Pathway: